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More recently, a bi-specific antibody, trontinemab, against TfR and A has been tested in non-human primates 94 and AD patients (NCT04023994)

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Transwell migration assay Transwell filters (Costar, Corning, Cambridge, MA, USA) with 8.0 m pores were used for the migration assay

Zinc is dynamically distributed within cells, where its compartmentalization across organelles, such as the nucleus, endoplasmic reticulum, Golgi apparatus, mitochondria, lysosomes, endosomes and peroxisomes, enables specialized functions crucial for organelle integrity and interorganelle communication